Effect of recipient gender and race on heart and kidney allograft survival

Transplant Proc. 1992 Dec;24(6):2670-1.

Abstract

Study of long-term survival of heart allografts shows that AA males and females have lower graft survival rates than those observed in NAC recipients. Primary kidney allografts in AA males, but not females, also display lower 5-year survival rates compared to those observed in the corresponding populations of NAC. Comparison of graft survival in the overall population of male and female recipients of kidney allografts shows that females have higher graft survival rates, probably as a result of better HLA matching. The level of alloantibody activity in posttransplantation sera is similar in the two populations, suggesting that factors other than HLA mismatching may contribute to the higher degree of graft failure in AA recipients.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actuarial Analysis
  • African Continental Ancestry Group*
  • Age Factors
  • Cadaver
  • European Continental Ancestry Group*
  • Follow-Up Studies
  • Graft Rejection / immunology*
  • Graft Rejection / mortality
  • Graft Survival / immunology*
  • HLA Antigens / immunology
  • Heart Transplantation / immunology*
  • Heart Transplantation / mortality
  • Histocompatibility Testing
  • Humans
  • Kidney Transplantation / immunology*
  • Kidney Transplantation / mortality
  • Postoperative Complications / immunology*
  • Postoperative Complications / mortality
  • Sex Factors
  • Survival Rate

Substances

  • HLA Antigens