Toward an understanding of the structural basis of translation

Genome Biol. 2003;4(12):237. doi: 10.1186/gb-2003-4-12-237. Epub 2003 Nov 19.

Abstract

The recently solved X-ray crystal structures of the ribosome have provided opportunities for studying the molecular basis of translation with a variety of methods including cryo-electron microscopy - where maps give the first glimpses of ribosomal evolution - and fluorescence spectroscopy techniques.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cryoelectron Microscopy
  • Humans
  • Peptide Elongation Factors / genetics
  • Peptide Elongation Factors / metabolism
  • Protein Biosynthesis*
  • RNA, Ribosomal / genetics
  • RNA, Ribosomal / metabolism
  • Ribosomes / genetics
  • Ribosomes / metabolism
  • Ribosomes / ultrastructure*

Substances

  • Peptide Elongation Factors
  • RNA, Ribosomal