Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

Eur J Pharmacol. 2003 Dec 15;482(1-3):339-41. doi: 10.1016/j.ejphar.2003.09.060.


3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30 degrees C) relative to normal laboratory temperature (21 degrees C). In the intravenous drug self-administration paradigm, hot temperature (30 degrees C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hot Temperature*
  • Interpersonal Relations*
  • Male
  • Motor Activity / drug effects*
  • Motor Activity / physiology
  • N-Methyl-3,4-methylenedioxyamphetamine / administration & dosage*
  • Rats
  • Rats, Wistar
  • Self Administration


  • N-Methyl-3,4-methylenedioxyamphetamine