Role of the natriuretic peptide system in cardiorenal protection

Arch Intern Med. 2003 Dec;163(22):2696-704. doi: 10.1001/archinte.163.22.2696.


Significant progress has been made in the understanding of the neurohormonal factors that contribute to the progression of chronic renal and cardiac failure and the development of target-organ damage in patients with hypertension and diabetes. We herein review some of these advances, including a new therapeutic strategy for potentially enhancing cardiorenal protection in patients with these disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / physiopathology*
  • Humans
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / physiopathology*
  • Natriuretic Peptides / physiology*
  • Protease Inhibitors / therapeutic use*


  • Natriuretic Peptides
  • Protease Inhibitors