The role of chromosomal translocation (15;19) in the carcinoma of the upper aerodigestive tract in children

Otolaryngol Head Neck Surg. 2003 Dec;129(6):698-704. doi: 10.1016/s0194-5998(03)01451-7.

Abstract

Objective: To further evaluate the role of chromosomal translocation (15;19) in the presentation of the carcinoma (CA) of the upper aerodigestive tract.

Study design and setting: A retrospective study at a tertiary care pediatric medical center.

Results: Seven patients with a mean age of 12 years presented with CA of nasopharynx (N = 2), sinonasal region (N = I), parotid gland (N = 2), or larynx (N = 2). Treatments included combinations of surgery (N = 5), chemotherapy (N = 5), and radiation therapy (N = 4). One patient with sinonasal CA and one patient with laryngeal CA had chromosomal translocation (15;19); these patients both died of their disease with a mean survival of 6 months. The 5 patients without translocation (15;19) responded well to treatment and are disease-free with a mean follow-up of 47 months.

Conclusion: The preliminary results appear to indicate poor prognosis associated with the presentation of chromosomal translocation (15;19) despite aggressive multi-modality treatment. Further investigation is needed to better understand the cause and relationship of the translocation (15;19) and aggressive behavior of these tumors.

MeSH terms

  • Adolescent
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / therapy
  • Child
  • Child, Preschool
  • Chromosomes, Human, 13-15
  • Chromosomes, Human, 19-20
  • Female
  • Humans
  • Laryngeal Neoplasms / diagnosis
  • Laryngeal Neoplasms / genetics*
  • Laryngeal Neoplasms / therapy
  • Male
  • Nasopharyngeal Neoplasms / diagnosis
  • Nasopharyngeal Neoplasms / genetics*
  • Nasopharyngeal Neoplasms / therapy
  • Paranasal Sinus Neoplasms / diagnosis
  • Paranasal Sinus Neoplasms / genetics*
  • Paranasal Sinus Neoplasms / therapy
  • Parotid Neoplasms / diagnosis
  • Parotid Neoplasms / genetics*
  • Parotid Neoplasms / therapy
  • Prognosis
  • Retrospective Studies
  • Translocation, Genetic / genetics*