PI3K/Akt and apoptosis: size matters

Oncogene. 2003 Dec 8;22(56):8983-98. doi: 10.1038/sj.onc.1207115.


Recent research has examined Akt and Akt-related serine-threonine kinases in signaling cascades that regulate cell survival and are important in the pathogenesis of degenerative diseases and in cancer. We seek to recapitulate the research that has helped to define the current understanding of the role of the Akt pathway under normal and pathologic conditions, also in view of genetic models of Akt function. In particular, we will evaluate the mechanisms of Akt regulation and the role of Akt substrates in Akt-dependent biologic responses in the decisions of cell death and cell survival. Here, we hope to establish the mechanisms of apoptosis suppression by Akt kinase as a framework for a more general understanding of growth factor-dependent regulation of cell survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • 3-Phosphoinositide-Dependent Protein Kinases
  • Animals
  • Apoptosis*
  • Cell Survival
  • Humans
  • Mice
  • Models, Animal
  • Models, Genetic
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases / physiology*
  • Phosphoric Monoester Hydrolases / physiology
  • Protein Serine-Threonine Kinases / physiology
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction
  • Tumor Suppressor Protein p53 / physiology
  • Tumor Suppressor Proteins / physiology


  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • 3-Phosphoinositide-Dependent Protein Kinases
  • AKT1 protein, human
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human