Homocysteinemia in psychiatric disorders: association with dementia and depression, but not schizophrenia in female patients

J Neural Transm (Vienna). 2003 Dec;110(12):1401-11. doi: 10.1007/s00702-003-0061-3. Epub 2003 Oct 24.


Homocysteinemia has been reported to be a risk factor for dementia, depression and also schizophrenia, the latter in a gender-specific manner. We have determined homocysteine in female inpatients suffering from various psychiatric diseases to further investigate a possible association between homocysteinemia and psychiatric disorders. Homocysteine was not elevated in schizophrenic females (mean, 11.6+/-5.8 micromol/l); in accordance with previous studies, homocysteinemia could be found frequently in dementia of different aetiology (mean, 17.2+/-6.7 micromol/l), but also to a slighter extent in depressive disorders (mean, 12.9+/-3.8 micromol/l), especially in elderly subjects. We thus suggest that homocysteinemia, at least in females, is an unspecific risk factor for organic brain disorders, but not endogenous psychoses.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Dementia / blood
  • Dementia / complications*
  • Depression / blood
  • Depression / complications*
  • Female
  • Homocysteine / blood*
  • Humans
  • Middle Aged
  • Risk Factors
  • Schizophrenia / blood
  • Schizophrenia / complications*


  • Homocysteine