The Information Centre for Rare Diseases (CIMR) of the Mario Negri Institute, has promoted a specific study on quality of life of patients with Takayasu's arteritis, a chronic vasculitis with unclear etiology, that affects primarily aorta and its main branches. The aim of the study is to assess the QoL of Italian Takayasu's arteritis patients referring to the CIMR, using the SF-36 Health Survey. The SF-36 questionnaire was submitted to 61 Takayasu arteritis patients who covered the inclusion criteria of the study, with a response rate of 85.25%, (6 males and 46 females). Expectedly, the overall SF-36 scores of the study population were lower compared to the general Italian population specifically with respect to General Health and Vitality scales. More extensive research would be required to explore gender differences suggested by the study.