Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure

Eur J Haematol. 2003 Nov;71(5):388-90. doi: 10.1034/j.1600-0609.2003.00123.x.


We describe a 63-yr-old patient diagnosed with chronic idiopathic myelofibrosis whose disease was treated with hydroxyurea for 2 yr. He developed respiratory symptoms that were extensively investigated including lung biopsy. Clinical, radiological and histological features were compatible with a diagnosis of hydroxyurea-induced pneumonitis. Following drug withdrawal there was remarkable improvement in clinical and radiological findings.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Hydroxyurea / adverse effects*
  • Male
  • Middle Aged
  • Pneumonia / chemically induced*
  • Pneumonia / diagnosis
  • Primary Myelofibrosis / complications
  • Primary Myelofibrosis / drug therapy*


  • Hydroxyurea