Heat shock proteins in cardiovascular disease a new therapeutic target

Cardiol Rev. Jan-Feb 2004;12(1):26-30. doi: 10.1097/01.crd.0000090894.70619.fa.

Abstract

Cells have the capability of defending themselves from various stressors by activating a genetic program with the production of substances known as heat shock proteins and their regulatory partners, the heat shock transcription factors. In this article, heat shock proteins are discussed, including their roles in pathophysiology and as possible pharmacologic targets to treat disease. Multiple investigations have demonstrated an elevation in heat shock proteins in patients with systemic hypertension, coronary artery disease, carotid atherosclerosis, and myocardial infarction and ischemia. As we further understand how to manipulate their expression, we can explore pharmacologic interventions and gene transfection techniques that can safely be used in humans.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / physiopathology*
  • Heat-Shock Proteins / drug effects
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / physiology*
  • Heat-Shock Response / genetics
  • Heat-Shock Response / physiology
  • Humans

Substances

  • Heat-Shock Proteins