PCR-based analysis of the TCR repertoire in human autoimmune diseases

Immunol Today. 1992 Sep;13(9):336-8. doi: 10.1016/0167-5699(92)90166-5.


Characterization of T cells at sites of autoimmune damage has been difficult. Now, however, polymerase chain reaction (PCR)-based methods are being used to analyse T-cell receptor (TCR) gene expression in such lesions. Here, Christopher Marguerie, Claudio Lunardi and Alex So summarize and interpret the most recent findings and describe the current understanding of TCR usage in autoimmune diseases.

Publication types

  • Review

MeSH terms

  • Autoantigens / immunology
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / immunology
  • Gene Rearrangement, T-Lymphocyte
  • Humans
  • Immunodominant Epitopes / immunology
  • Lymphocyte Activation
  • Polymerase Chain Reaction*
  • Receptors, Antigen, T-Cell / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • T-Lymphocyte Subsets / immunology


  • Autoantigens
  • Immunodominant Epitopes
  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta