A strategy to improve the efficacy of vaccination against tuberculosis and leprosy

Immunol Today. 1992 Sep;13(9):342-5. doi: 10.1016/0167-5699(92)90168-7.

Abstract

The pathogens responsible for leprosy, tuberculosis and the leishmaniases can induce different classes of immunity, but protection is provided only by a cell-mediated response. Here, Peter Bretscher proposes a strategy to achieve an immunological imprint that ensures a stable cell-mediated response upon natural infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • BCG Vaccine / administration & dosage*
  • BCG Vaccine / immunology
  • Bacterial Vaccines* / administration & dosage
  • Bacterial Vaccines* / immunology
  • Disease Susceptibility / immunology
  • Dose-Response Relationship, Immunologic
  • Genetic Predisposition to Disease
  • Humans
  • Hypersensitivity, Delayed / immunology
  • Immunity, Cellular
  • Immunity, Innate / genetics
  • Immunity, Innate / immunology
  • Leishmania tropica / immunology
  • Leishmaniasis, Cutaneous / immunology
  • Leishmaniasis, Cutaneous / parasitology
  • Leprosy / epidemiology
  • Leprosy / immunology
  • Leprosy / prevention & control*
  • Mice
  • Mice, Inbred BALB C / immunology
  • Mice, Inbred BALB C / parasitology
  • Mycobacterium bovis / classification
  • Mycobacterium bovis / immunology
  • Mycobacterium leprae / immunology*
  • Mycobacterium tuberculosis / immunology*
  • Rats
  • Tuberculosis / epidemiology
  • Tuberculosis / immunology
  • Tuberculosis / prevention & control*
  • Vaccination*

Substances

  • BCG Vaccine
  • Bacterial Vaccines