Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis

Cancer Cell. 2003 Nov;4(5):393-403. doi: 10.1016/s1535-6108(03)00271-x.


The vasculature in the angiogenic stages of a mouse model of pancreatic islet carcinogenesis was profiled in vivo with phage libraries that display short peptides. We characterized seven peptides distinguished by their differential homing to angiogenic progenitors, solid tumors, or both. None homed appreciably to normal pancreatic islets or other organs. Five peptides selectively homed to neoplastic lesions in the pancreas and not to islet beta cell tumors growing subcutaneously, xenotransplant tumors from a human cancer cell line, or an endogenously arising squamous cell tumor of the skin. Three peptides with distinctive homing to angiogenic islets, tumors, or both colocalized with markers that identify endothelial cells or pericytes. One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biomarkers, Tumor*
  • Blood Vessels / physiopathology*
  • Endothelial Cells / metabolism
  • Immunohistochemistry
  • Insulinoma / diagnosis
  • Insulinoma / metabolism
  • Islets of Langerhans / physiopathology*
  • Mice
  • Neoplasm Staging
  • Neovascularization, Pathologic / diagnosis
  • Neovascularization, Pathologic / metabolism*
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / metabolism
  • Peptide Library*
  • Peptides / metabolism*
  • Pericytes / metabolism
  • Proto-Oncogene Proteins c-sis / metabolism


  • Biomarkers, Tumor
  • Peptide Library
  • Peptides
  • Proto-Oncogene Proteins c-sis