Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database

Eur Urol. 2004 Jan;45(1):53-7; discussion 57. doi: 10.1016/j.eururo.2003.08.008.


Objectives: To understand the clinical behavior of renal oncocytoma in a retrospective analysis of a European multicentric nephrectomies database.

Methods: The records of 891 patients who underwent surgical resection of renal neoplasm were reviewed. Relevant clinical and pathological data for each patient were retrieved in a database.

Results: Thirty-two (3.6%) cases of renal oncocytoma were identified. Twenty patients (62.5%) were asymptomatic. No case of lymphatic invasion or metastatic disease, nor any evidence of vascular or fat tissue invasion was found. Thirty-one cases (96%) exhibited low mitotic activity. In one case the presence of renal clear cell carcinoma (diameter: 1.5cm) was found. After a median follow-up of 42 months, 87.5% of patients were alive with no evidence of tumor, while 9.3% of patients had died for non-malignant causes. One patient had not treated the tumor surgically and was disease-free at a 27-month follow-up.

Conclusions: Renal oncocytoma is a benign neoplasm, characterized by slow growth and excellent prognosis after surgery. Nephron sparing techniques may be adequate for tumor removal.

Publication types

  • Multicenter Study

MeSH terms

  • Adenocarcinoma, Clear Cell / diagnosis
  • Adenocarcinoma, Clear Cell / epidemiology
  • Adenoma, Oxyphilic / diagnosis*
  • Adenoma, Oxyphilic / epidemiology
  • Adenoma, Oxyphilic / surgery*
  • Adult
  • Aged
  • Databases, Factual
  • Europe
  • Female
  • Humans
  • Incidence
  • Kidney Neoplasms / diagnosis*
  • Kidney Neoplasms / epidemiology
  • Kidney Neoplasms / surgery*
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary / diagnosis
  • Neoplasms, Multiple Primary / epidemiology
  • Prognosis
  • Retrospective Studies