Modulation of the beta1-3 voltage-gated sodium channels in rat vestibular and facial nuclei after unilateral labyrinthectomy and facial nerve section: an in situ hybridization study

I Vassias; T Patko; P-P Vidal; C de Waele

doi:10.1016/j.molbrainres.2003.10.001

Modulation of the beta1-3 voltage-gated sodium channels in rat vestibular and facial nuclei after unilateral labyrinthectomy and facial nerve section: an in situ hybridization study

Brain Res Mol Brain Res. 2003 Dec 12;120(1):73-8. doi: 10.1016/j.molbrainres.2003.10.001.

Authors

I Vassias¹, T Patko, P-P Vidal, C de Waele

Affiliation

¹ LNRS (CNRS-Paris 5), UMR 7060 Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75270 Paris, Cedex 06, France.

PMID: 14667580
DOI: 10.1016/j.molbrainres.2003.10.001

Abstract

We investigated whether the production of the mRNAs for the auxiliary beta subunits of the Na channels are modulated in deafferented medial vestibular nucleus (MVN) and in axotomized facial motoneurons. No beta1-3 mRNAs modulation was detected at any time following unilateral labyrinthectomy in the deafferented and intact medial vestibular nucleus. In contrast, beta1 gene expression in the axotomized facial nucleus decreased compared to controls as soon as day post-lesion 3.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoradiography
Axotomy / methods
Ear, Inner / metabolism
Ear, Inner / surgery*
Facial Nerve / cytology
Facial Nerve / metabolism*
Facial Nerve / surgery
In Situ Hybridization*
Male
Motor Neurons / metabolism*
Oligonucleotide Probes / metabolism
Otologic Surgical Procedures
Protein Subunits / metabolism
Rats
Rats, Long-Evans
Sodium Channels / metabolism*
Time Factors
Vestibular Nuclei / metabolism*
Vestibular Nuclei / surgery

Substances

Oligonucleotide Probes
Protein Subunits
Sodium Channels