Role of type 1 and type 2 T helper cells in allergic diseases

Curr Opin Immunol. 1992 Dec;4(6):788-93. doi: 10.1016/0952-7915(92)90063-k.


Various characteristics of atopic allergic disorders seem to be causally related with the activation of allergen-specific T helper lymphocytes with a type 2 cytokine secretion profile, including high levels of interleukin-4 and interleukin-5. These cytokines are responsible for the occurrence of elevated levels of serum allergen-specific IgE and eosinophilia and play an important role in local inflammatory reactions.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Immunoglobulin E / biosynthesis
  • Inflammation / immunology
  • T-Lymphocyte Subsets / physiology
  • T-Lymphocytes, Helper-Inducer / physiology*


  • Immunoglobulin E