Compositional biases and polyalanine runs in humans

Genetics. 2003 Nov;165(3):1613-7. doi: 10.1093/genetics/165.3.1613.


Human proteins containing polyalanine tracts tend to have runs of other amino acids and their open reading frames (ORFs) display a biased codon usage. Their alanine, glycine, proline, and histidine content strongly correlates with the GC content of the third codon base, suggesting that the compositional specificity of these proteins is dictated to a great extent by the evolution of their ORFs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Codon
  • Humans
  • Open Reading Frames
  • Peptides / genetics*


  • Codon
  • Peptides
  • polyalanine