Differential associations between entorhinal and hippocampal volumes and memory performance in older adults

Behav Neurosci. 2003 Dec;117(6):1150-60. doi: 10.1037/0735-7044.117.6.1150.


Magnetic resonance imaging-derived entorhinal and hippocampal volumes were measured in 14 nondemented, community-dwelling older adults. Participants were selected so that memory scores from 2 years prior to scanning varied widely but were not deficient relative to age-appropriate norms. A median split of these memory scores defined high-memory and low-memory groups. Verbal memory scores at the time of imaging were lower, and entorhinal and hippocampal volumes were smaller, in the low-memory group than in the high-memory group. Left entorhinal cortex volume showed the strongest correlation (r= .79) with immediate recall of word lists. Left hippocampal volume showed the strongest correlation (r= .57) with delayed paragraph recall. These results suggest that entorhinal and hippocampal volumes are related to individual differences in dissociable kinds of memory performance among healthy older adults.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Brain Mapping*
  • Entorhinal Cortex / anatomy & histology
  • Entorhinal Cortex / physiology*
  • Female
  • Functional Laterality
  • Hippocampus / anatomy & histology
  • Hippocampus / physiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory / physiology*
  • Middle Aged
  • Organ Size
  • Reference Values
  • Statistics as Topic
  • Verbal Learning / physiology*