Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma

Allergy. 2004 Jan;59(1):61-4. doi: 10.1046/j.1398-9995.2003.00352.x.


Background: Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5-15% of the exposed population suggesting an underlying genetic susceptibility.

Methods: To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects.

Results: Neither the distribution of HLA class I antigens nor the distribution of TNF-alpha A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects.

Conclusions: These results suggest that HLA class I antigens and TNF-alpha A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma / chemically induced
  • Asthma / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease*
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced
  • Occupational Diseases / genetics
  • Polymorphism, Genetic*
  • Probability
  • Prognosis
  • Reference Values
  • Risk Assessment
  • Sensitivity and Specificity
  • Toluene 2,4-Diisocyanate / adverse effects*
  • Tumor Necrosis Factor-alpha / genetics*


  • Histocompatibility Antigens Class I
  • Tumor Necrosis Factor-alpha
  • Toluene 2,4-Diisocyanate