Meta-analysis of randomized clinical trials on the usefulness of acetylcysteine for prevention of contrast nephropathy

Am J Cardiol. 2003 Dec 15;92(12):1454-8. doi: 10.1016/j.amjcard.2003.08.059.


Multiple small studies of oral N-acetylcysteine for prevention of contrast nephropathy have been performed, demonstrating variable efficacy. We performed a meta-analysis of the randomized clinical trials to clarify the degree of benefit.

Publication types

  • Meta-Analysis

MeSH terms

  • Acetylcysteine / therapeutic use*
  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / prevention & control*
  • Antioxidants / therapeutic use*
  • Contrast Media / adverse effects*
  • Creatinine / blood
  • Humans
  • Randomized Controlled Trials as Topic


  • Antioxidants
  • Contrast Media
  • Creatinine
  • Acetylcysteine