The mitochondrial genome of the thermal dimorphic fungus Penicillium marneffei is more closely related to those of molds than yeasts

FEBS Lett. 2003 Dec 18;555(3):469-77. doi: 10.1016/s0014-5793(03)01307-3.


We report the complete sequence of the mitochondrial genome of Penicillium marneffei, the first complete mitochondrial DNA sequence of a thermal dimorphic fungus. This 35 kb mitochondrial genome contains the genes encoding ATP synthase subunits 6, 8, and 9 (atp6, atp8, and atp9), cytochrome oxidase subunits I, II, and III (cox1, cox2, and cox3), apocytochrome b (cob), reduced nicotinamide adenine dinucleotide ubiquinone oxireductase subunits (nad1, nad2, nad3, nad4, nad4L, nad5, and nad6), ribosomal protein of the small ribosomal subunit (rps), 28 tRNAs, and small and large ribosomal RNAs. Analysis of gene contents, gene orders, and gene sequences revealed that the mitochondrial genome of P. marneffei is more closely related to those of molds than yeasts.

Publication types

  • Comparative Study

MeSH terms

  • Base Sequence
  • Cell Nucleus / genetics
  • DNA, Mitochondrial / genetics
  • Gene Components / genetics
  • Genes / genetics
  • Genes, rRNA / genetics
  • Genome, Fungal*
  • Humans
  • Likelihood Functions
  • Mitochondria / genetics*
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Penicillium / genetics*
  • Phylogeny
  • RNA, Transfer / genetics
  • Sequence Analysis, DNA
  • Yeasts / genetics*


  • DNA, Mitochondrial
  • RNA, Transfer