Semiconductor quantum dots for photodynamic therapy

J Am Chem Soc. 2003 Dec 24;125(51):15736-7. doi: 10.1021/ja0386905.


The applicability of semiconductor QDs in photodynamic therapy (PDT) was evaluated by studying the interaction between CdSe QDs with a known silicon phthalocyanine PDT photosensitizer, Pc4. The study revealed that the QDs could be used to sensitize the PDT agent through a fluorescence resonance energy transfer (FRET) mechanism, or interact directly with molecular oxygen via a triplet energy-transfer process (TET). Both mechanisms result in the generation of reactive singlet oxygen species that can be used for PDT cancer therapy.

MeSH terms

  • Cadmium Compounds / chemistry
  • Fluorescence Resonance Energy Transfer
  • Indoles / chemistry*
  • Oxygen / chemistry*
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry*
  • Quantum Dots*
  • Selenium Compounds / chemistry
  • Semiconductors*


  • Cadmium Compounds
  • Indoles
  • Photosensitizing Agents
  • Selenium Compounds
  • phthalocyanine Pc 4
  • Oxygen