Iso-enzymatic variability of Leishmania infantum in Spain

Ann Trop Med Parasitol. 2003 Oct;97 Suppl 1:57-64. doi: 10.1179/000349803225002534.


In many areas of the Mediterranean basin, leishmaniasis can now be found in HIV-positive individuals. Such cases of Leishmania/HIV co-infection are relatively common in southern Europe, Spain being the country that has reported the greatest number. Since 1984, 359 Spanish isolates of Leishmania infantum have been characterized at the Instituto de Salud Carlos III in Madrid. Most (94.6%) of the isolates came from HIV-positive patients. The results of iso-enzymatic analysis indicated a high level of variability among the isolates, the visceralization in HIV-positive individuals of variants considered to be dermotropic in the immunocompetent, and the appearance of new zymodemes among the HIV-positive human population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / epidemiology
  • AIDS-Related Opportunistic Infections / parasitology*
  • Animals
  • Comorbidity
  • Genetic Variation / genetics
  • Humans
  • Immunocompetence / genetics
  • Isoenzymes / analysis*
  • Leishmania infantum / enzymology*
  • Leishmania infantum / genetics
  • Leishmaniasis, Visceral / epidemiology
  • Leishmaniasis, Visceral / parasitology*
  • Spain / epidemiology
  • Time Factors


  • Isoenzymes