Rig-1 a new member of Robo family genes exhibits distinct pattern of expression during mouse development

Gene Expr Patterns. 2004 Jan;4(1):99-103. doi: 10.1016/s1567-133x(03)00142-x.

Abstract

The Robo genes encode a family of proteins that are the receptors for the midline repellent Slits and play a role in axon guidance. In addition to Robo1 and Robo2, Rig-1 has been recently identified in mouse as a novel member of the Robo family of proteins. As a first step in elucidating the role of Rig-1 during vertebrate development, we characterised the expression of Rig-1 by in situ hybridisation together with Robo1 and Robo2 in the spinal cord and other tissues of the mouse embryo. Our results show that Rig-1 has a dynamic pattern of expression in the developing CNS. In the spinal cord Rig-1 shows overlapping but distinct pattern of expression with Robo1 and Robo2.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / embryology
  • Brain / metabolism
  • Embryo, Mammalian / embryology
  • Embryo, Mammalian / metabolism*
  • Gene Expression Profiling*
  • Gene Expression Regulation, Developmental
  • In Situ Hybridization
  • Membrane Proteins / genetics*
  • Mice
  • Nerve Tissue Proteins / genetics*
  • Receptors, Cell Surface
  • Receptors, Immunologic / genetics
  • Spinal Cord / embryology
  • Spinal Cord / metabolism

Substances

  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Robo2 protein, mouse
  • Robo3 protein, mouse
  • roundabout protein