Insulin resistance in latent autoimmune diabetes of adulthood

Ann N Y Acad Sci. 2003 Nov;1005:374-7. doi: 10.1196/annals.1288.062.


Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA-2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type 1 diabetes, and similar to that in long-term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long-term type 1 diabetes with respect to insulin resistance and BMI, but occurs at an older age.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoantibodies / analysis
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Female
  • Glutamate Decarboxylase / immunology
  • Humans
  • Insulin Resistance*
  • Isoenzymes / immunology
  • Male
  • Middle Aged


  • Autoantibodies
  • ICA512 autoantibody
  • Isoenzymes
  • Glutamate Decarboxylase
  • glutamate decarboxylase 2