Obesity-induced inflammatory changes in adipose tissue

J Clin Invest. 2003 Dec;112(12):1785-8. doi: 10.1172/JCI20514.


Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.

Publication types

  • Comment

MeSH terms

  • Adipose Tissue / metabolism*
  • Animals
  • Biological Evolution
  • Diabetes Mellitus, Type 2 / metabolism
  • Humans
  • Inflammation*
  • Macrophages / metabolism
  • Models, Biological
  • Obesity* / metabolism
  • Transcription, Genetic