Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide

J Bacteriol. 2004 Jan;186(1):248-52. doi: 10.1128/JB.186.1.248-252.2004.

Abstract

Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H(2)O(2) and untreated controls. The data indicate that the early response of P. aeruginosa to H(2)O(2) consists of an upregulation of protective mechanisms and a downregulation of primary metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Profiling
  • Gene Expression Regulation, Bacterial*
  • Genome, Bacterial*
  • Hydrogen Peroxide / pharmacology*
  • Oxidants / pharmacology*
  • Oxidative Stress
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / metabolism
  • RNA, Messenger / metabolism
  • Transcription, Genetic*

Substances

  • Bacterial Proteins
  • Oxidants
  • RNA, Messenger
  • Hydrogen Peroxide