Abstract
Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H(2)O(2) and untreated controls. The data indicate that the early response of P. aeruginosa to H(2)O(2) consists of an upregulation of protective mechanisms and a downregulation of primary metabolism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Gene Expression Profiling
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Gene Expression Regulation, Bacterial*
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Genome, Bacterial*
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Hydrogen Peroxide / pharmacology*
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Oxidants / pharmacology*
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Oxidative Stress
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / metabolism
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RNA, Messenger / metabolism
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Transcription, Genetic*
Substances
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Bacterial Proteins
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Oxidants
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RNA, Messenger
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Hydrogen Peroxide