Blockade of mitral/tufted cell habituation to odors by association with reward: a preliminary note

Brain Res. 1992 Oct 23;594(1):143-5. doi: 10.1016/0006-8993(92)91039-h.


Association of odor and reward during the early postnatal period modifies rat pup behavioral responses and olfactory bulb neural responses to subsequent presentations of that odor. Recent evidence has shown that olfactory bulb output neurons, mitral/tufted cells, receive convergent odor and reward inputs. The present report demonstrates that contiguous odor-reward pairings prevent mitral/tufted cell habituation to the odor that normally occurs to repeated odor-only stimulation. It is hypothesized that the maintenance of olfactory bulb responses to conditioned odors during training may allow for activation of long-term memory mechanisms.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Conditioning, Operant / physiology*
  • Habituation, Psychophysiologic / drug effects*
  • Neurons / drug effects*
  • Odorants*
  • Olfactory Bulb / cytology
  • Olfactory Bulb / drug effects*
  • Rats
  • Rats, Wistar
  • Reward*