Colistin for Klebsiella pneumoniae-associated sepsis

Clin Infect Dis. 2004 Jan 1;38(1):e7-9. doi: 10.1086/380461. Epub 2003 Dec 4.


Klebsiella pneumoniae that was resistant to all available antibiotics (minimum inhibitory concentration of imipenem, 32 microg/mL), including carbapenems, was isolated from blood samples obtained from a 48-year-old patient in the intensive care unit. The patient developed septic shock, which was successfully treated with colistin, the only antibiotic with activity against this multidrug-resistant strain.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Colistin / therapeutic use*
  • Drug Resistance, Multiple / physiology*
  • Humans
  • Klebsiella Infections / drug therapy*
  • Klebsiella pneumoniae* / drug effects
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Sepsis / drug therapy*


  • Anti-Bacterial Agents
  • Colistin