Synthesis of nearly monodisperse polystyrene-polypeptide block copolymers via polymerisation of N-carboxyanhydrides

Chem Commun (Camb). 2003 Dec 7:(23):2944-5. doi: 10.1039/b308990h.

Abstract

Primary amine hydrochlorides promote a well-controlled ring-opening polymerisation of Z-L-lysine-N-carboxyanhydride in DMF at 40-80 degrees C; the polystyrene-poly(Z-L-lysine) block copolymers synthesised exhibit a very narrow molecular weight distribution, close to a Poisson distribution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anhydrides / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Polylysine / chemistry*
  • Polymers / chemical synthesis*
  • Polymers / chemistry*
  • Polystyrenes / chemistry*
  • Temperature

Substances

  • Anhydrides
  • Polymers
  • Polystyrenes
  • Polylysine