The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D196-9. doi: 10.1093/nar/gkh043.


Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The Gen THREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computational Biology
  • Databases, Genetic*
  • Genome
  • Genomics*
  • Humans
  • Information Storage and Retrieval
  • Internet
  • Protein Folding
  • Protein Structure, Tertiary
  • Proteins / chemistry*
  • Proteins / genetics*
  • Proteome / chemistry
  • Proteome / genetics
  • Proteomics
  • Software


  • Proteins
  • Proteome