IntAct: an open source molecular interaction database

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D452-5. doi: 10.1093/nar/gkh052.


IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotations of the interacting proteins. A web service allows direct computational access to retrieve interaction networks in XML format. IntAct currently contains approximately 2200 binary and complex interactions imported from the literature and curated in collaboration with the Swiss-Prot team, making intensive use of controlled vocabularies to ensure data consistency. All IntAct software, data and controlled vocabularies are available at

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computational Biology
  • Databases, Protein*
  • Humans
  • Information Storage and Retrieval
  • Internet
  • Protein Binding*
  • Proteins / metabolism*
  • Software
  • User-Computer Interface
  • Vocabulary, Controlled


  • Proteins