[Cognitive disturbances in patients with tics and Tourette's syndrome and their correction with encephabol]

Zh Nevrol Psikhiatr Im S S Korsakova. 2003;103(11):10-4.
[Article in Russian]


Ninety-four patients with tick hyperkinesis (57) and Tourette's syndrome (37) were studied. Neuropsychological examination revealed memory, attention and audio-motor disturbances and symptoms of dysgraphia and dyslexia. Cognitive impairment may develop before ticks appearance and aggravate during hyperkinesis exacerbation. In the patients with Tourette's syndrome, cortical dysfunctions were mostly pronounced. These cognitive disturbances correlated with the indices of spectral analysis of bioelectrical brain activity in frontal and temporal areas. In 83 patients, an efficacy of encephabol treatment combined with basic therapy was studied. Encephabol given in dosage 200-300 mg daily to patients aged 5-7 years and 600 mg--to those aged over 7 years during 6 weeks significantly improved memory, attention and praxis function.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Age Factors
  • Brain / physiopathology
  • Child
  • Cognition Disorders / drug therapy*
  • Cognition Disorders / etiology
  • Cognition Disorders / physiopathology
  • European Union
  • Female
  • Humans
  • Male
  • Pyrithioxin / administration & dosage
  • Pyrithioxin / therapeutic use*
  • Tic Disorders / complications
  • Tic Disorders / drug therapy*
  • Tic Disorders / physiopathology
  • Time Factors
  • Tourette Syndrome / complications
  • Tourette Syndrome / drug therapy*
  • Tourette Syndrome / physiopathology
  • Treatment Outcome


  • Pyrithioxin