An evidence-based approach to diabetic foot infections

Am J Surg. 2003 Nov 28;186(5A):44S-54S; discussion 61S-64S. doi: 10.1016/j.amjsurg.2003.10.008.


Foot infections are a major complication of diabetes mellitus and contribute to the development of gangrene and lower extremity amputation. Recent evidence indicates that persons with diabetes are at greater risk for infection because of underlying neuropathy, peripheral vascular disease, and impaired responses to infecting organisms. This article reviews the underlying pathophysiology, causes, microbiology, and current management concepts for this potentially limb-threatening complication. Multidisciplinary management consisting of teams of specialists with a focus on limb preservation can make significant improvements in outcomes, including a reduction in rates of lower extremity amputation.

Publication types

  • Review

MeSH terms

  • Diabetic Foot* / classification
  • Diabetic Foot* / etiology
  • Diabetic Foot* / physiopathology
  • Diabetic Foot* / therapy
  • Humans
  • Skin Diseases, Bacterial* / classification
  • Skin Diseases, Bacterial* / etiology
  • Skin Diseases, Bacterial* / physiopathology
  • Skin Diseases, Bacterial* / therapy