The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression

FEBS Lett. 1992 Dec 21;314(3):285-8. doi: 10.1016/0014-5793(92)81490-d.


The murine gene for the NPY-1 receptor subtype for neuropeptide Y was characterized by DNA sequencing and expression studies. It comprises three exons with a 6,400 bp 5'-untranslated and a 80 bp internal intronic sequence. The 5'-flanking region of this gene lacks TATA or CCAAT consensus sequences in the proximity to the multiple transcription initiation sites. A 1,300 bp genomic fragment of the 5'-flanking region drives the expression of the lacZ reporter gene in NG108-15 cells and primary cultured neurons but not in glial and human embryonic kidney cells. In addition, it contains consensus sequences for various transcription factors including cAMP- and glucocorticoid-responsive elements.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA
  • Mice
  • Molecular Sequence Data
  • Organ Specificity / genetics
  • Promoter Regions, Genetic
  • Receptors, Neuropeptide Y / genetics*
  • Restriction Mapping


  • Receptors, Neuropeptide Y
  • DNA

Associated data

  • GENBANK/S39996
  • GENBANK/S40001
  • GENBANK/S40008
  • GENBANK/S40009
  • GENBANK/S40010
  • GENBANK/X72580
  • GENBANK/Z18280
  • GENBANK/Z18281
  • GENBANK/Z18282
  • GENBANK/Z18283