Inactivation of the fis gene leads to reduced growth rate

FEMS Microbiol Lett. 1992 Nov 15;78(1):85-8. doi: 10.1016/0378-1097(92)90292-v.


The FIS protein (factor for inversion stimulation) is known to activate the transcription of rRNA and tRNA operons in Escherichia coli. In this report the growth behaviour of a fis bacterium was studied under steady-state conditions and in competition experiments with a wild-type bacterium in a chemostat. The growth rate of the fis bacterium was reduced as compared to that of an isogenic wild-type and this reduction increased linearly with increasing growth rate. A similar result was obtained in competition experiments in a chemostat, with the selection factor increasing linearly with the growth rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / genetics*
  • Escherichia coli / genetics
  • Escherichia coli / growth & development*
  • Escherichia coli Proteins*
  • Factor For Inversion Stimulation Protein
  • Gene Expression Regulation, Bacterial*
  • Integration Host Factors
  • Operon


  • Carrier Proteins
  • Escherichia coli Proteins
  • Factor For Inversion Stimulation Protein
  • Integration Host Factors
  • integration host factor, E coli