A prospective, randomised clinical evaluation of a new safety-orientated injectable drug administration system in comparison with conventional methods

Anaesthesia. 2004 Jan;59(1):80-7. doi: 10.1111/j.1365-2044.2004.03457.x.


Fifteen anaesthetists were observed while providing anaesthesia for 15 pairs of adult cardiac surgical operations, using conventional methods for one of each pair and a new drug administration system designed to reduce error for the other. Aspects of each method were rated by users on 10-cm visual analogue scales (10 being best). The new system was rated more favourably than conventional methods in terms of safety (median [range] = 8.1 [6.8-9.7] vs. 7.1 [2.6-9.3] cm; p = 0.001) and usability (8.5 [5.9-9.4] vs. 7.5 [3.2-9.8] cm; p=0.027). The new system saved preparation time both before anaesthesia (median [range] = 180 [32-480] vs. 360 [120-600] s; p=0.013) and during anaesthesia (10 [2-38] vs. 12 [10-60] s; p=0.009). Prefilled syringes for the new system increased costs by euro 23.00 per anaesthetic (p = 0.041), but this increase is likely to be offset by the potential of the new system to decrease costly iatrogenic harm by preventing drug error.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anesthetics, Intravenous / administration & dosage*
  • Anesthetics, Intravenous / economics
  • Attitude of Health Personnel
  • Cardiac Surgical Procedures
  • Drug Costs
  • Drug Delivery Systems*
  • Drug Labeling
  • Humans
  • Medication Errors / prevention & control*
  • Prospective Studies
  • Risk Management / methods
  • Syringes


  • Anesthetics, Intravenous