Weighing the role of hypothalamic feeding neurotransmitters

Neuron. 2003 Dec 18;40(6):1059-61. doi: 10.1016/s0896-6273(03)00809-2.


Growing health problems related to obesity have focused considerable attention on a number of neurotransmitters, particularly hypothalamic neuropeptides, involved in regulating energy homeostasis and food intake. As the fast-acting transmitters GABA and glutamate underlie the majority of fast synaptic activity in the hypothalamus, understanding neuropeptide modulation of amino acid transmitter actions may be key to a full appreciation of how the brain controls caloric balances.

Publication types

  • Review

MeSH terms

  • Animals
  • Feeding Behavior / physiology*
  • Glutamic Acid / physiology*
  • Humans
  • Hypothalamus / physiology*
  • Neurotransmitter Agents / physiology
  • Obesity / physiopathology
  • gamma-Aminobutyric Acid / physiology*


  • Neurotransmitter Agents
  • Glutamic Acid
  • gamma-Aminobutyric Acid