Signal transduction of bone morphogenetic protein receptors

Cell Signal. 2004 Mar;16(3):291-9. doi: 10.1016/j.cellsig.2003.08.011.


Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Bone Morphogenetic Protein Receptors
  • Carrier Proteins / metabolism
  • DNA-Binding Proteins / metabolism
  • Feedback, Physiological
  • MAP Kinase Signaling System
  • Mitogen-Activated Protein Kinases / metabolism
  • Models, Biological
  • Receptors, Growth Factor / metabolism*
  • Signal Transduction*
  • Smad Proteins
  • Trans-Activators / metabolism
  • p38 Mitogen-Activated Protein Kinases


  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • DNA-Binding Proteins
  • Receptors, Growth Factor
  • Smad Proteins
  • TAB2 protein, human
  • Trans-Activators
  • Mitogen-Activated Protein Kinases
  • p38 Mitogen-Activated Protein Kinases
  • Bone Morphogenetic Protein Receptors