The measurement and interpretation of age-specific vaccine efficacy

Int J Epidemiol. 1992 Oct;21(5):1014-20. doi: 10.1093/ije/21.5.1014.


The age-specific efficacy of a vaccine depends upon the mechanism of vaccine action and the force of infection in the unvaccinated subpopulation. Consequently, inferences concerning the persistence of vaccine-induced immunity cannot in general be made directly from age-specific vaccine efficacy estimates. The definition, estimation and interpretation of age-specific vaccine efficacy measures are discussed using simple models of vaccine action. The methods are applied to data on measles and pertussis vaccines.

MeSH terms

  • Age Factors
  • Antibody Formation
  • Bias
  • Data Interpretation, Statistical
  • Humans
  • Immunity
  • Vaccines / immunology*


  • Vaccines