Pathology of cervical cancer

Cancer J. Sep-Oct 2003;9(5):335-47. doi: 10.1097/00130404-200309000-00003.


Squamous cell carcinoma is the most common malignant cervical tumor, but the incidence of adenocarcinomas has been rising during the past few decades. This article discusses the epidemiology and pathogenesis of the squamous cell carcinoma, its clinical and histologic features, including microinvasive carcinoma, its histologic grade, and variant tumors. The prognostic impact of these features and the differential diagnosis are also covered. The second portion of this article is devoted to the glandular tumors of the cervix, including adenocarcinoma in situ and invasive adenocarcinoma and its variants. The differential diagnosis of these tumors with tumor like glandular lesions is given special attention. Finally, less common malignant cervical tumors are covered, with an emphasis being placed on their significance.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / pathology*
  • Carcinoma, Squamous Cell / pathology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Neoplasm Staging
  • Uterine Cervical Neoplasms / pathology*