Antidiarrhoeal activity of Rhus javanica ripen fruit extract in albino mice

Fitoterapia. 2004 Jan;75(1):39-44. doi: 10.1016/j.fitote.2003.08.015.


The antidiarrhoeal effects of the methanolic extract of Rhus javanica ripen fruits (MERJ) were investigated by employing four experimental models of diarrhoea in Swiss albino mice. MERJ treated mice, showed significant reduction in the faecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by MgSO4 and gastrointestinal motility after charcoal meal administration in the albino mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Antidiarrheals / administration & dosage
  • Antidiarrheals / pharmacology*
  • Antidiarrheals / therapeutic use
  • Castor Oil
  • Diarrhea / chemically induced
  • Diarrhea / prevention & control
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Fruit
  • Gastrointestinal Motility / drug effects*
  • Mice
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rhus*


  • Antidiarrheals
  • Plant Extracts
  • Castor Oil