A 62-year-old man with amyloid deposition associated with generalized morphea-like scleroderma is described. He had been occupationally exposed to organic solvents. Physical examination showed sclerosis of fingers, forearms, and trunk. Erythema was noted on the border of patchy sclerotic plaques on his chest and back. In addition, firm miliary, keratotic papules were found on the lateral forearms. Amyloid deposition was demonstrated by Congo-red stain at papillary layers of overlying sclerotic dermis in the biopsied specimen taken from the left forearm. As far as we know, amyloid deposition associated with generalized morphea-like scleroderma has not been reported until now.