Transfusion-related acute lung injury (TRALI) following allogeneic stem cell transplant for acute myeloid leukemia

Am J Hematol. 2004 Jan;75(1):48-51. doi: 10.1002/ajh.10452.


Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion characterized by dyspnea, hypoxemia, hypotension, fever, and bilateral pulmonary infiltrates. Although the frequency is estimated at 1/1,120 to 1/5,000 transfusions, few cases have been reported after hematopoietic stem cell transplant. We report a case occurring in an allogeneic transplant recipient who developed acute respiratory distress and bilateral pulmonary infiltrates 2 hr after a platelet transfusion due to the presence of anti granulocyte antibody HNA-3a in the product. As there is a wide differential diagnosis for pulmonary infiltrates developing post transplant, TRALI may be under-recognized and should be considered in this setting.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Antibodies / analysis
  • Antibodies / immunology
  • Female
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Leukemia, Myeloid, Acute / therapy*
  • Lung Diseases / diagnostic imaging
  • Lung Diseases / etiology*
  • Lung Diseases / immunology
  • Platelet Transfusion / adverse effects
  • Radiography, Thoracic
  • Respiratory Distress Syndrome / diagnostic imaging
  • Respiratory Distress Syndrome / etiology
  • Respiratory Distress Syndrome / immunology
  • Transplantation, Homologous / adverse effects


  • Antibodies