Abstract
Discorhabdins S, T, and U (1-3), three new discorhabdin analogues, have been isolated from a deep-water marine sponge of the genus Batzella. These discorhabdin analogues showed in vitro cytotoxicity against PANC-1, P-388, and A-549 cell lines. The isolation and structure elucidation of discorhabdins S, T, and U are described.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Bahamas
-
Cell Line, Tumor
-
Drug Screening Assays, Antitumor
-
Humans
-
Inhibitory Concentration 50
-
Leukemia P388
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Porifera / chemistry*
-
Pyrroles / chemistry
-
Pyrroles / isolation & purification*
-
Pyrroles / pharmacology
-
Quinones / chemistry
-
Quinones / isolation & purification*
-
Quinones / pharmacology
-
Spiro Compounds / chemistry
-
Spiro Compounds / isolation & purification*
-
Spiro Compounds / pharmacology
Substances
-
Pyrroles
-
Quinones
-
Spiro Compounds
-
discorhabdin S
-
discorhabdin T
-
discorhabdin U