Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells

Biofactors. 2003;18(1-4):265-70. doi: 10.1002/biof.5520180229.


The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells (PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q10 in cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Free Radicals / metabolism*
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Glutathione Peroxidase / genetics*
  • Humans
  • Male
  • Mitochondria / metabolism
  • Prostate / drug effects
  • Prostate / enzymology*
  • Prostate / ultrastructure
  • Prostatic Neoplasms / enzymology*
  • Prostatic Neoplasms / pathology
  • RNA, Messenger / analysis
  • Tumor Cells, Cultured
  • Ubiquinone / pharmacology*


  • Free Radicals
  • RNA, Messenger
  • Ubiquinone
  • Glutathione Peroxidase