Non-peptide Fibrinogen Receptor Antagonists. 1. Discovery and Design of Exosite Inhibitors

J Med Chem. 1992 Nov 27;35(24):4640-2. doi: 10.1021/jm00102a020.

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Amino Acid Sequence
  • Binding Sites
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism
  • Fibrinogen / metabolism
  • Humans
  • Molecular Sequence Data
  • Molecular Structure
  • Oligopeptides / pharmacology
  • Platelet Aggregation Inhibitors / chemical synthesis*
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Membrane Glycoproteins / antagonists & inhibitors*
  • Platelet Membrane Glycoproteins / metabolism
  • Tirofiban
  • Tyrosine / analogs & derivatives
  • Tyrosine / chemical synthesis
  • Tyrosine / pharmacology
  • Umbilical Veins

Substances

  • Oligopeptides
  • Platelet Aggregation Inhibitors
  • Platelet Membrane Glycoproteins
  • Tyrosine
  • Adenosine Diphosphate
  • Fibrinogen
  • Tirofiban