Structure-activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues Against H-bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue

J Med Chem. 1992 Dec 11;35(25):4764-6. doi: 10.1021/jm00103a015.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Binding, Competitive
  • Brain / drug effects
  • Brain / metabolism
  • Cocaine / analogs & derivatives*
  • Discrimination Learning
  • Mazindol / metabolism
  • Rats
  • Structure-Activity Relationship

Substances

  • Mazindol
  • Cocaine