Isolation of alpha-glusosidase inhibitors from hyssop (Hyssopus officinalis)

Phytochemistry. 2004 Jan;65(1):91-7. doi: 10.1016/j.phytochem.2003.10.009.

Abstract

alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of dried hyssop (Hyssopus officinalis) leaves. Active principles against alpha-glucosidase, prepared from rat small intestine acetone powders, were isolated and characterized. The structures of these isolated compounds were determined to be (7S, 8S)-syringoylglycerol-9-O-(6'-O-cinnamoyl)-beta-D-glucopyranoside and (7S, 8S)-syringoylglycerol 9-O-beta-D-glucopyranoside by analysis of physical and spectroscopic data (FDMS, 1H NMR, 13C NMR, HMQC, and HMBC experiments) together with chemical syntheses.

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Glycoside Hydrolase Inhibitors*
  • Lamiaceae / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves / chemistry
  • Rats
  • Spectrometry, Mass, Fast Atom Bombardment

Substances

  • Enzyme Inhibitors
  • Glucosides
  • Glycoside Hydrolase Inhibitors