Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response

Trends Immunol. 2004 Jan;25(1):17-24. doi: 10.1016/


Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic reticulum (ER), the site of antibody biosynthesis. Recent discoveries have provided insights into how this expansive secretory machinery is built, equipped and maintained. The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the ER, regulates the expression and activity of X-box binding protein 1, a transcription factor required for plasma-cell development. The UPR pathway therefore senses conditions in the ER--the very compartment where antibodies are formed--and directs events required for humoral immunity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Cell Differentiation / immunology*
  • Endoplasmic Reticulum / immunology
  • Humans
  • Lymphocyte Activation / immunology*
  • Plasma Cells / cytology*
  • Plasma Cells / immunology
  • Signal Transduction / genetics
  • Signal Transduction / immunology*
  • Transcription Factors / immunology


  • Transcription Factors